Health
Novel Treatment Shows Promise Against Rare Cancer In Kids
Researchers revealed Wednesday that a novel treatment based on supercharged immune cells appeared to act against tumors in youngsters with a rare type of cancer.
Six weeks following therapy, nine of the 27 youngsters in the Italian research showed no signs of cancer, while two later relapsed and died.
The immune system is already being helped by CAR-T cell therapy to fight leukemia and other blood cancers. Experts say this is the first time researchers have gotten such promising results with solid tumors. This gives people hope that this method can treat other types of cancer.
It’s too early to call it a cure for neuroblastoma, a type of nerve tissue cancer that typically begins in childhood in the adrenal glands near the kidneys in the belly.
Standard treatment might be severe depending on the cancer stage and other considerations, requiring chemotherapy, surgery, and radiation. The youngsters in the research had cancer that had returned or was difficult to treat.
When the three-year research concluded, eleven children remained alive, including several who only partially reacted to treatment and required repeat injections of the modified cells.
Standard treatment might be severe depending on the cancer stage and other considerations.
“Those kids were all destined to die without that therapy,” said Dr. Carl June of the University of Pennsylvania, a pioneer of CAR-T therapy who was not involved in the new study.
“No one has ever had patients respond like this before, so we just don’t know what it’ll look like in a decade,” June said. “With these promising results, there will undoubtedly be more trials.”
CAR-T cell therapy uses the immune system to develop “living drugs” capable of locating and destroying tumors. T cells from the patient’s blood are collected and reinforced in the lab before being reintroduced to the patient through IV, where they multiply further.
The US Food and Drug Administration has approved six CAR-T cell treatments for blood malignancies. Some of the early rise cases were cured.
However, success with solid tumors has been difficult to come by. Researchers from the Vatican’s Bambino Gesu pediatric hospital in Rome conducted the most recent study.
Dr. Robbie Majzner of Stanford University School of Medicine, who was not involved in the current study, said, “They seem to have found a unique combination” to allow the transformed cells to multiply initially, then last a long time to continue their cancer-killing function.
Dr. Franco Locatelli, a study co-author, included a safety switch to kill the cells if a patient had a severe reaction. When one patient had issues, they flicked the safety switch, demonstrating that it functioned. However, they later discovered that the patient’s issue was caused by a brain hemorrhage unrelated to the CAR-T cells.
CAR-T therapy often causes a side effect called “cytokine release syndrome,” which is an overreaction of the immune system in young people. According to the researchers, it can be serious but is modest in most cases.
They concluded CAR-T therapy was “feasible and safe in treating high-risk neuroblastoma.”
SOURCE – (AP)
Health
Growth Hormone Why Athletes Take HGH
Growth hormone is a protein synthesized, secreted, and released by somatotropes (cells in the anterior pituitary gland) and transported through the bloodstream to target tissues, stimulating growth. It has a variety of functions, from promoting growth and tissue repair to producing immune function and controlling mood.
More recently, HGH has also been shown to have anabolic effects on the body. When given biologically at levels not typically found in humans, it can make muscles grow faster and more robust.
Growth hormone raises insulin-like growth factor levels in blood and tissues, directly contributing to increased muscle size and strength during exercise. According to the Mayo Clinic, growth hormone is often referred to as “the fountain of youth” because it is thought to be responsible for long-term health and fitness.
Why does someone need extra prescribed growth hormone?
The most common reasons someone would take HGH prescribed by a doctor are:
1. People with a deficiency of natural Growth hormone. This is where the body has completely lost its ability to produce growth hormone or has lost the power of some or most of its growth-producing glands to make enough growth hormone.
2. Aging adults have a decreased ability to produce growth hormones. In both aging children and adults, the pituitary gland in the brain decreases its ability to make enough growth hormone.
3. Athletes who want to improve their performance in their chosen sports use Growth hormones as a performance-enhancing drug (PED). Athletes wish to HGH because it enables them to exercise harder for longer, with better recovery times, and train harder for more hours daily. HGH also helps to increase the number of muscle fibers, the body’s natural protein booster.
4. People with severe medical conditions. People need HGH prescribed by a doctor if they have been diagnosed with a disorder where their bodies do not produce enough natural growth hormone or if their pituitary gland does not produce enough growth hormone for them to live life normally – for example, with kids needing growth hormones due to pituitary gland surgery or after chemotherapy.
Benefits of Human growth hormone.
With a prescribed HGH regimen, you may find some or all of the following benefits:
1. Increased energy, improved mood, and better sleep patterns can help you feel better and improve your overall health. But remember that you should always talk to your physician or a healthcare provider before taking HGH for any reason.
2. Reduced recovery times between workouts, athletic practices, and events, allowing you to work out harder and longer. You should have increases in lean muscle mass, endurance, and overall strength with human growth hormone use over time.
3. Increased adrenaline levels result in a faster and more intense workout or an increased ability to push yourself.
4. Improved mood and increased motivation. HGH can enhance mood, helping you feel happier and easier going. You may also be able to get out of bed in the morning feeling refreshed and ready to take on the day after taking HGH instead of over-the-counter sleep aids.
5. Improve sexual drive, motivation, and performance, which can help you enjoy intimacy with your partner
6. Increases in muscle mass and strength.
7. If you cannot participate in physical activities due to health issues or a lack of strength, taking HGH may make it possible to participate in what you love. In some cases, people who use HGH with good results can continue participating in sports even after their growth hormones are stopped.
8. Increased bone density can help protect your body from fractures during athletic activity.
Why Are Athletes Using HGH?
Why do athletes use Growth Hormones? The main reasons are as follows:
1. Increased Muscle Growth and Tissue Repair:
2. When athletes use HGH, they can increase their muscles’ size more quickly than expected, leading to more explosive movements that result in faster and more powerful athletics.
3. HGH Helps to Speed Up How Quickly Your Body Recovers: HGH can speed up muscle growth and help your body recover from the damage caused by exercise and training more quickly. This allows athletes to train harder and longer every week.
4. Increased Fat Burning:
5. HGH can boost your body’s natural fat-burning process so that you will burn fat more quickly than average. This can lead to a leaner physique, ideal for athletes looking to achieve their weight class.
HGH side effects on athletes can be dangerous without the control of a medic because it is impossible to hide from the cheaters, who compare notes on improving their efficiency with their colleagues or rivals.
The increased muscle mass achieved by taking human growth hormone for athletes has side effects, including tumor growth, varying sugar levels, and an increased risk of diabetes.
Why can HGH be Dangerous?
1. HGH can be hazardous. This is especially true when used by athletes not following medical advice. HGH on athletes can cause a variety of things like diabetes, enlarged heart, failure of organs and tissue, abnormal blood pressure and high blood pressure, hardening of blood vessels, kidney problems, and thyroid cancer.
2. It is also dangerous for people who use HGH for bodybuilding. The opportunity of having severe health problems is excellent. In some cases, the growth of facial features may become uneven, causing a person to have a p
3. protruding forehead, long nose, and thin lips. Other reported side effects directly resulting from HGH include headaches, nervousness, and joint pain.
The risks of taking human growth hormone can be significant to an athlete’s health trying to enhance their performance. While taking HGH and getting benefits without unwanted side effects is still possible, only a doctor will know if you are a good candidate for this treatment.
Health
Walking Pneumonia Cases Among Children On the Rise in Canada
According to medical professionals, there has been an unusual rise in the number of severe and complex cases of walking pneumonia that are afflicting patients who are significantly younger in hospitals throughout Canada.
The division director of pediatric infectious diseases stated that the disease is prevalent in children and typically manifests as a benign form of pneumonia. However, a greater number of children are developing a severe form of the disease.
According to physicians, mycoplasma pneumonia is prevalent among school-aged children. It is informally referred to as walking pneumonia.
They also noted that individuals who exhibit more severe symptoms, such as respiratory difficulties, may necessitate treatment for the contagious pneumonia caused by Mycoplasma pneumoniae bacteria.
Dr. Isaac Bogoch, an infectious diseases specialist, stated that Canada is likely experiencing the same trends as the United States, with infections being most prevalent in the autumn.
The Public Health Agency of Canada (PHAC) does not monitor this specific disease; however, it does monitor other respiratory illnesses in Canada and reports the trends in the Respiratory Virus Detection Surveillance System Report, the FluWatch+ Surveillance Program, and the COVID-19 epidemiology update.
Rubin stated that conducting experiments is challenging. His discussions with his colleagues have provided him with anecdotal information regarding the observed trends. Doctors have reported a backlog in tests and delays in receiving results due to increased cases.
Health specialists have indicated that patients may undergo various diagnostic procedures, including blood tests, nose swabs, throat swabs, physical examinations, measurement of oxygen and carbon dioxide levels in the blood, and chest X-rays.
Specialized polymerase chain reaction (PCR) assays are more frequently accessible to patients in the hospital.
Walking Pneumonia Cases in British Columbia
According to data provided by the B.C. Centre for Disease Control (BCCDC) and B.C. Children’s Hospital, the number of walking pneumonia infections in B.C. is higher than in previous years, with the highest incidence among individuals under 20.
They referenced BCCDC’s Public Health Laboratory data, the Canadian Sentinel Practitioner Surveillance Network, and B.C. Children’s Hospital.
Walking Pneumonia Cases from other regions of Canada
A prominent women’s and children’s hospital in Halifax has also reported an increase in the number of cases of walking pneumonia. It increased from 11 last year to 113 as of September.
Dr. Karen Gripp, the emergency department’s medical director at HSC Children’s Hospital in Winnipeg, has reported that the number of pediatric patients in the emergency department with pneumonia this autumn has increased by a “significant amount.” However, the specific type of pneumonia is still uncertain.
The Saskatchewan Health Authority emergency departments, including Jim Pattison Children’s Hospital, have not yet reported any reports that suggest the illness is pervasive.
Trending News:
Sophie Grégoire Trudeau Promotes Mental Health Awareness
Health
Sophie Grégoire Trudeau Promotes Mental Health Awareness
Sophie Grégoire Trudeau, the wife of Canadian Prime Minister Justin Trudeau, recently underlined the crucial need for mental health awareness and support. Grégoire Trudeau spoke at a community gathering in Toronto on her personal experiences with mental health issues.
Grégoire Trudeau, an advocate for a variety of social problems, emphasized the importance of mental health alongside physical health. “We must break the stigma surrounding mental illness,” she said, urging people to seek assistance and support without fear of being judged.
Her frank discussion struck a chord with many guests, creating an environment where people felt empowered to share their difficulties and tales. The event included a panel of mental health professionals who examined the rising prevalence of anxiety and depression, particularly among young people.
They stressed the importance of having access to mental health resources and the value of community support in supporting well-being.
Grégoire Trudeau reiterated these thoughts, urging governments and organizations to spend more on mental health services and programs. Her speech also emphasized the impact of the COVID-19 pandemic on mental health in Canada.
She stated that isolation and uncertainty have aggravated existing mental health difficulties, making it critical for society to emphasize mental well-being.
“We are all in this together, and we need to look out for one another,” she told us.
The program finished with a call to action, asking participants to start conversations about mental health in their communities.
Grégoire Trudeau’s dedication to this subject mirrors a larger trend to de-stigmatize mental health concerns and create a supportive atmosphere for individuals who suffer from them.
As mental health remains a major issue in Canada and worldwide, Grégoire Trudeau’s activism highlights the significance of compassion, empathy, and proactive measures in dealing with this vital part of health.
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