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Scientists Are Testing MRNA Vaccines To Protect Cows And People Against Bird Flu

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The bird flu outbreak in dairy cows in the United States has prompted the creation of new, next-generation mRNA vaccines, similar to COVID-19 shots, currently being tested in animals and humans.

Next month, the USDA will begin evaluating a vaccine created by University of Pennsylvania researchers by administering it to calves. The theory is that if cow vaccination protects dairy workers, there would be fewer opportunities for the virus to infect people and change in ways that could lead to human-to-human transmission.

Meanwhile, the US Department of Health and Human Services has been speaking with manufacturers about potential mRNA flu vaccinations for humans, which, if necessary, could supplement millions of bird flu vaccine doses currently in the government’s possession.

“If there’s a pandemic, there’s going to be a huge demand for vaccine,” said Richard Webby, flu researcher at St. Jude Children’s Research Hospital in Memphis. “The more different (vaccine manufacturing) platforms that can respond to that, the better.”

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Scientists Are Testing MRNA Vaccines To Protect Cows And People Against Bird Flu

Since 2020, the bird flu virus has spread to a wider range of animal species in several countries. It was discovered in dairy herds in the United States in March, although researchers believe it was present in cows as early as December. This week, the USDA revealed that it had been discovered in alpacas for the first time.

At least three people working on farms with infected cows were diagnosed with bird flu, albeit their symptoms were mild.

However, previous forms of the same H5N1 flu virus have been extremely fatal to people in other parts of the world. Officials are taking precautions in case the virus mutates and becomes more lethal or spreads more easily from person to person.

Most flu vaccinations have traditionally been manufactured using an egg-based technology that has been in use for over 70 years. It entails injecting a candidate virus into fertilized chicken eggs, which are then cultured for several days to allow the viruses to develop. Fluid from the eggs is extracted and utilized to make vaccines, with deceased or weakened viruses priming the immune system.

Some flu vaccines are manufactured in massive cell vats rather than eggs, and they are similarly vulnerable to bird flu-related supply limits.

Officials say they already have two candidate vaccines for humans that appear to be well-matched to the avian flu virus seen in dairy animals in the United States. The Centers for Disease Control and Prevention developed the seed strain from the circulating avian flu virus.

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Scientists Are Testing MRNA Vaccines To Protect Cows And People Against Bird Flu

Federal health experts say the government possesses hundreds of thousands of vaccine doses in pre-filled syringes and vials that could be distributed within weeks if necessary.

They also claim to have mass antigens capable of producing over 10 million additional doses, which could be packed, finished, and distributed in months. CSL Seqirus, a manufacturer of cell-based flu vaccine, stated this week that the government has engaged it to fill and finish around 4.8 million of those doses. Health officials in the United States stated last week that the work might be completed by late summer.

However, flu vaccine production lines are currently working on seasonal vaccinations for this fall, which would have to be delayed to produce millions of additional doses of bird flu vaccine. So, the government has taken a different, faster approach: the mRNA technology used to create the principal vaccinations against COVID-19.

Messenger RNA vaccines are created by combining a small part of the virus’s genetic material. The genetic blueprint instructs the body to produce a protein that helps build immunity.

Moderna Pharmaceuticals already has a bird flu mRNA vaccine that is in very early human development. Moderna stated, “we are in discussions with the US government on advancing our pandemic flu candidate.”

Similar work has been done at Pfizer. In December, company researchers administered an mRNA vaccine to human volunteers against a bird flu strain comparable to—but not identical to—the one seen in cows. Since then, researchers conducted a lab trial in which blood samples from those participants were exposed to the strain found on dairy farms and discovered “notable increases in antibody responses,” according to Pfizer.

Penn immunologist Scott Hensley developed the experimental doses of the cow vaccine in collaboration with mRNA pioneer and Nobel laureate Drew Weissman. Hensley stated that the vaccination is identical to the Moderna one for humans.

In preliminary tests, mice and ferrets exhibited substantial avian flu virus-fighting antibodies following immunization.

In another experiment, researchers vaccinated one set of ferrets and then purposely infected them, comparing the results to ferrets who had not been vaccinated. Hensley stated that all vaccinated animals lived, but the unvaccinated did not.

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Scientists Are Testing MRNA Vaccines To Protect Cows And People Against Bird Flu

“The vaccine was really successful,” said Webby, whose lab collaborated with Hensley last year.

The cow study will resemble the preliminary testing conducted on smaller animals. The objective is to vaccinate roughly ten calves, half with one dose and half with another. Then, their blood will be collected and tested to determine how many avian flu-fighting antibodies were created.

According to Hensley, the USDA study will need to first find the appropriate dose for such a huge animal before examining whether it protects them like it did smaller animals.

What “scares me the most is the amount of interaction between cattle and humans,” Hensley stated.

“We’re not talking about an animal that lives on a mountain top,” he stated. “If this was a bobcat outbreak I’d feel bad for the bobcats, but that’s not a big human risk.”

If a vaccine reduces the amount of virus in the cow, “then eventually we reduce the chance that a mutant virus that spreads in humans will emerge,” he explained.

SOURCE – (AP)

Kiara Grace is a staff writer at VORNews, a reputable online publication. Her writing focuses on technology trends, particularly in the realm of consumer electronics and software. With a keen eye for detail and a knack for breaking down complex topics. Kiara delivers insightful analyses that resonate with tech enthusiasts and casual readers alike. Her articles strike a balance between in-depth coverage and accessibility, making them a go-to resource for anyone seeking to stay informed about the latest innovations shaping our digital world.

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Cases Of The US Flu Season Are Rising, While Vaccinations Are Behind Schedule.

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(AP Photo/Nam Y. Huh, File)

(VOR News) – The U.S. flu season has begun, according to health experts, who also noted a sharp rise in cases countrywide on Friday.

Significant increases were noted by the Centres for Disease Control and Prevention in a number of indicators, such as laboratory tests and ED visits. “For the past few weeks, it has been increasing steadily.” “Yes, we are in flu season right now,” CDC’s Alicia Budd said.

Last week, flu-like sickness was reported at elevated or very elevated levels in 13 states, roughly twice as many as the week before. Dr. William Schaffner, an infectious disease specialist at Vanderbilt University, says Tennessee is seeing a spike in sickness in the Nashville area.

Schaffner said, “Influenza cases have been increasing, but they have increased significantly in the last week.” He noted that up to 25% of patients in a nearby clinic, which is a gauge of illness trends, have flu-like symptoms.

An early focal point was Louisiana.

Our Lady of the Lake Regional Medical Centre, the largest private hospital in the state, in Baton Rouge, has infectious diseases specialist Dr. Catherine O’Neal, who said, “This week is a significant turning point as individuals are affected by the flu.” “Parents frequently say, ‘I have the flu and can’t go to work,’ and ‘Where can I get a flu test?'”

Fever, cough, sore throat, and other influenza-like symptoms are caused by a variety of viruses. COVID-19 is one of them. Another flu season common disease that causes cold-like symptoms but poses serious hazards to infants and the elderly is respiratory syncytial virus (RSV).

Recent CDC numbers indicate a decline in COVID-19 hospitalisations since the summer. According to CDC wastewater data, COVID-19 activity is modest nationwide but elevated in the Midwest.

Although RSV hospitalisations are still marginally more common than flu admissions, they started to rise before flu season cases and currently show signs of perhaps stabilising. RSV activity is low nationwide, but wastewater data shows that it is high in the South.

Based on a number of indicators, such as laboratory results from hospitalised patients and outpatient clinics, as well as the percentage of ED visits that resulted in an influenza diagnosis at discharge, the CDC declared the start of the flu season.

According to Budd, it is too early in the season to determine the effectiveness of the influenza vaccine, and no type of virus seems to be more common.

The flu season last winter was classified as “moderate” overall, but it continued for 21 weeks, and the CDC estimates that 28,000 people died from the virus. With 205 paediatric deaths reported, the situation was particularly dangerous for kids. It was the largest number ever recorded for a conventional influenza season.

The prolonged flu season was probably one of the reasons, Budd added.

The lack of influenza vaccinations was one of the contributing factors. The CDC reports that 80% of children who passed away and had verified vaccination status and were of the right age for flu shots were not completely immunised.

Children’s immunisation rates are drastically lower this year. About 41% of people had a flu shot as of December 7, which is similar to the percentage at the same time last year. For youngsters, the figure is steady, although it is lower than in the previous year, when 44% received an influenza vaccination, according to CDC data.

About 21% of adults and 11% of children are fully vaccinated against COVID-19, which is still a poor vaccination rate.

Influenza experts advise everyone to get vaccinated, especially as people get ready for holiday gatherings where respiratory diseases could spread widely.

“This virus also has the potential to spread from person to person at all those happy, pleasant, and heartwarming events,” Schaffner said. “flu season Vaccination remains a viable option.”

However, Louisiana’s health department announced on Friday that it was rescinding its COVID-19 and flu vaccination recommendations. According to an official, the department’s current position is that people should speak with their doctors about whether the immunisations are suitable for their situation.

The department’s spokesperson, Emma Herrock, did not respond to follow-up questions regarding the policy. Dr. Ralph Abraham, the state’s surgeon general, has expressed concerns in the past regarding the COVID-19 vaccine’s effectiveness and safety.

SOURCE: AP

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Social Security Change Approved By Senate Despite Fiscal Concerns

King Charles Could Millions Annually from Renting His Properties

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Social Security Change Approved By Senate Despite Fiscal Concerns

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(VOR News) – On Saturday, the U.S. Congress passed a plan to increase Social Security retirement payouts for some retirees who receive public pensions, a move that critics say will further erode the program’s financial stability. Among these pensioners are former firefighters and police officers.

The Social Security Fairness Act was passed by the Senate on a bipartisan vote of 76-20 just after midnight. The act may lower payments for those receiving pensions and aims to repeal provisions that have existed for 20 years.

The House of Representatives passed the bill last month by a vote of 327-75, meaning that if the Senate also approves it, it would be delivered to Democratic President Joe Biden to become law.

The White House dodged enquiries regarding Social Security’s objectives.

In order to limit government benefits for certain higher-paid employees who are also getting pensions, the measure will reverse a long-standing change to the program. It has become increasingly common in recent years for municipal employees, such as postal workers and firefighters, to face pay limitations.

The vast majority of Americans do not take part in pension plans that provide a fixed return on investment, instead relying on their own savings and Social Security. According to data from the Department of Labour, only 10% of private sector employees in the US are covered by pension plans.

The new rules apply to about 3 percent of Social Security users, or more than 2.5 million people in the United States. Legislators are heavily influenced by the workers and retirees impacted by these rules, and the powerful advocacy organisations that speak for them have been using the legislative process to push for a legislative cure.

According to retirement experts, some retirees may be able to earn hundreds of dollars more in government benefits each month as a result of the move.

According to a Congressional Budget Office analysis, the bill is expected to cost approximately $196 billion over the next 10 years. As a result, federal budget experts are worried that the change could negatively affect the program’s already fragile financial status.

In an interview with the Bipartisan Policy Centre, Emerson Sprick, associate director of economic policy, said he was frustrated by “the overwhelming support in Congress for the contrary of what policy researchers concur on is quite frustrating.”

Instead of eliminating current formulas, we could improve them.

Among these changes is the Social Security Administration’s increased disclosure of the anticipated monetary benefits for these public sector workers.

The Committee for a Responsible Federal Budget, a nonpartisan fiscal think tank, has voiced concerns that the additional cost will impact the program’s ability to continue.

Maya MacGuineas, the organization’s leader, made the declaration, saying, “We are hastening towards our own fiscal ruin.”

“It is noteworthy that lawmakers are in a position to shorten the timeframe by six months, as there are just nine years left before the trust fund for the biggest program in the country runs out.”

Senator Ted Cruz, a Republican, said on the Senate floor on Wednesday that the bill in its current form would “throw granny over the cliff.”

According to what he stated, “every senator who votes to impose a burden of $200 billion on the Social Security Trust Fund is opting to put the interests of senior citizens who have contributed to Social Security and earned those benefits in jeopardy.”

Those who favoured the legislation said that the question of what would happen to Social Security could be settled later.

“Those are significantly longer-term concerns that we must collaboratively address,” a supporter of the idea Senator Michael Bennett told Reuters when asked if the move would affect the government’s capacity to be viable.

SOURCE: BR

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King Charles Could Millions Annually from Renting His Properties

Man Creates Candy Cane Car to Spread Christmas Cheer

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King Charles Could Millions Annually from Renting His Properties

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Estimated Annual Rental Income of £1.4 Million

A recent analysis suggests that King Charles might earn over £1 million each year by renting out royal properties to holidaymakers.

The Royal Family’s historic houses and mansions are popular holiday rentals, contributing significantly to the Palace’s revenue.

Pikl Insurance estimates that the royals may earn up to £118,775.85 per month, or around £1,425,310.20 per year, from their holiday rental portfolio. Even after accounting for cancellations, the monarchy is anticipated to generate a net annual income of somewhat more over £1.4 million.

Estimated Annual Rental Income of £1.4 Million

The four primary royal properties accepting public bookings are Balmoral Castle, Castle of Mey’s Captain House, Restormel Manor, and Dumfries House, according to Express.co.uk. Cottages at Balmoral Castle in Scotland are expected to generate £36,798.30 per month after accounting for cancellations.

According to the numbers, the 500-year-old Restormel Manor in Cornwall is the most profitable of them all, earning a solid £47,082 every month. The resort, located in the Fowey Valley, has four booking spaces and six converted barns.

Dumfries House in Ayrshire, Scotland, adds an estimated £31,185.63 and offers 25 rooms for booking. The Castle of Mey’s Captain House in the Scottish Highlands is estimated to generate a more modest £3,709.92 per month, despite the fact that the entire property is available for booking.

The analysts stated, “While the Royal Family’s primary role is undoubtedly to serve the nation, it is clear that their properties are also a valuable asset.” These estimates highlight the royal estate’s considerable financial potential and provide an intriguing peek into the monarchy’s corporate operations.”

Royal Family received £86.3 million from the taxpayer-funded Sovereign Grant in the previous fiscal year, according to official numbers released in July.

All revenues from the Crown Estate, which includes royal households, forestry, agriculture, and offshore wind, are paid directly to the Treasury, with a portion of this money, now 12%, returned to the Royal Family to finance their tasks.

The records also cover a period of jubilation, including the coronation and festivities surrounding the King and Queen’s crowning in May of last year.

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