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Scientists Are Testing MRNA Vaccines To Protect Cows And People Against Bird Flu

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MRNA | Pixa Bay Image

The bird flu outbreak in dairy cows in the United States has prompted the creation of new, next-generation mRNA vaccines, similar to COVID-19 shots, currently being tested in animals and humans.

Next month, the USDA will begin evaluating a vaccine created by University of Pennsylvania researchers by administering it to calves. The theory is that if cow vaccination protects dairy workers, there would be fewer opportunities for the virus to infect people and change in ways that could lead to human-to-human transmission.

Meanwhile, the US Department of Health and Human Services has been speaking with manufacturers about potential mRNA flu vaccinations for humans, which, if necessary, could supplement millions of bird flu vaccine doses currently in the government’s possession.

“If there’s a pandemic, there’s going to be a huge demand for vaccine,” said Richard Webby, flu researcher at St. Jude Children’s Research Hospital in Memphis. “The more different (vaccine manufacturing) platforms that can respond to that, the better.”

MRNA

MRNA | Pixa Bay Image

Scientists Are Testing MRNA Vaccines To Protect Cows And People Against Bird Flu

Since 2020, the bird flu virus has spread to a wider range of animal species in several countries. It was discovered in dairy herds in the United States in March, although researchers believe it was present in cows as early as December. This week, the USDA revealed that it had been discovered in alpacas for the first time.

At least three people working on farms with infected cows were diagnosed with bird flu, albeit their symptoms were mild.

However, previous forms of the same H5N1 flu virus have been extremely fatal to people in other parts of the world. Officials are taking precautions in case the virus mutates and becomes more lethal or spreads more easily from person to person.

Most flu vaccinations have traditionally been manufactured using an egg-based technology that has been in use for over 70 years. It entails injecting a candidate virus into fertilized chicken eggs, which are then cultured for several days to allow the viruses to develop. Fluid from the eggs is extracted and utilized to make vaccines, with deceased or weakened viruses priming the immune system.

Some flu vaccines are manufactured in massive cell vats rather than eggs, and they are similarly vulnerable to bird flu-related supply limits.

Officials say they already have two candidate vaccines for humans that appear to be well-matched to the avian flu virus seen in dairy animals in the United States. The Centers for Disease Control and Prevention developed the seed strain from the circulating avian flu virus.

MRNA

MRNA | Pixa Bay Image

Scientists Are Testing MRNA Vaccines To Protect Cows And People Against Bird Flu

Federal health experts say the government possesses hundreds of thousands of vaccine doses in pre-filled syringes and vials that could be distributed within weeks if necessary.

They also claim to have mass antigens capable of producing over 10 million additional doses, which could be packed, finished, and distributed in months. CSL Seqirus, a manufacturer of cell-based flu vaccine, stated this week that the government has engaged it to fill and finish around 4.8 million of those doses. Health officials in the United States stated last week that the work might be completed by late summer.

However, flu vaccine production lines are currently working on seasonal vaccinations for this fall, which would have to be delayed to produce millions of additional doses of bird flu vaccine. So, the government has taken a different, faster approach: the mRNA technology used to create the principal vaccinations against COVID-19.

Messenger RNA vaccines are created by combining a small part of the virus’s genetic material. The genetic blueprint instructs the body to produce a protein that helps build immunity.

Moderna Pharmaceuticals already has a bird flu mRNA vaccine that is in very early human development. Moderna stated, “we are in discussions with the US government on advancing our pandemic flu candidate.”

Similar work has been done at Pfizer. In December, company researchers administered an mRNA vaccine to human volunteers against a bird flu strain comparable to—but not identical to—the one seen in cows. Since then, researchers conducted a lab trial in which blood samples from those participants were exposed to the strain found on dairy farms and discovered “notable increases in antibody responses,” according to Pfizer.

Penn immunologist Scott Hensley developed the experimental doses of the cow vaccine in collaboration with mRNA pioneer and Nobel laureate Drew Weissman. Hensley stated that the vaccination is identical to the Moderna one for humans.

In preliminary tests, mice and ferrets exhibited substantial avian flu virus-fighting antibodies following immunization.

In another experiment, researchers vaccinated one set of ferrets and then purposely infected them, comparing the results to ferrets who had not been vaccinated. Hensley stated that all vaccinated animals lived, but the unvaccinated did not.

mrna

MRNA | Pixa Bay Image

Scientists Are Testing MRNA Vaccines To Protect Cows And People Against Bird Flu

“The vaccine was really successful,” said Webby, whose lab collaborated with Hensley last year.

The cow study will resemble the preliminary testing conducted on smaller animals. The objective is to vaccinate roughly ten calves, half with one dose and half with another. Then, their blood will be collected and tested to determine how many avian flu-fighting antibodies were created.

According to Hensley, the USDA study will need to first find the appropriate dose for such a huge animal before examining whether it protects them like it did smaller animals.

What “scares me the most is the amount of interaction between cattle and humans,” Hensley stated.

“We’re not talking about an animal that lives on a mountain top,” he stated. “If this was a bobcat outbreak I’d feel bad for the bobcats, but that’s not a big human risk.”

If a vaccine reduces the amount of virus in the cow, “then eventually we reduce the chance that a mutant virus that spreads in humans will emerge,” he explained.

SOURCE – (AP)

Kiara Grace is a staff writer at VORNews, a reputable online publication. Her writing focuses on technology trends, particularly in the realm of consumer electronics and software. With a keen eye for detail and a knack for breaking down complex topics, Kiara delivers insightful analyses that resonate with tech enthusiasts and casual readers alike. Her articles strike a balance between in-depth coverage and accessibility, making them a go-to resource for anyone seeking to stay informed about the latest innovations shaping our digital world.

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Prosecutors intend to retry Karen Read following a mistrial declared in the murder case.

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Greg Derr/The Patriot Ledger

(VOR News) – Karen Read, a Massachusetts woman accused of killing her police officer lover in 2022, had her trial declared a mistrial by a judge on Monday.

The verdict was rendered on the fifth day of a nine-week trial that took place in a courtroom outside Boston. During the trial, Read’s attorneys claimed that the death of 46-year-old John O’Keefe was a police cover-up.

Prosecutors claim that on January 29, 2022, Karen Read, 44, crashed her Lexus SUV into her fiancé, leaving him for dead.

Read was accused of DUI manslaughter, second-degree murder, and escaping the scene of a tragic collision.

Six men and six women made up the jury, and on Monday afternoon the foreman wrote to Norfolk County Superior Court Judge Beverly Cannone to express that despite their best efforts, the panel remained divided. The letter stated that while some believed the prosecution’s case to be weak, others believed there was sufficient evidence to condemn Read.

The jurors were devoted to their duty, but they were also “deeply divided by fundamental differences in our opinions and state of mind,” as they wrote to Cannone.

Cannone scheduled a status hearing for later this month following the mistrial.

In addition to thanking O’Keefe’s family, the district attorney’s office declared a retrial.

Reporters were informed outside the courthouse by Karen Read lawyer,

Alan Jackson, that the prosecution had employed dishonest detectives and an improper investigation. “We will not give up on our struggle,” he declared.

That morning, O’Keefe was discovered to be unresponsive and declared deceased. The medical examiner concluded that the patient died from blunt force injuries to the brain and hypothermia.

In order to hide an attack that O’Keefe had during a party at the apartment where his body was discovered, her defense team alleged that the police conspired to frame her.

The chief investigator in the case, Massachusetts state trooper Michael Proctor, was accused by the defense of falsifying evidence, neglecting to look into O’Keefe’s death, and sending derogatory messages and epithets about Karen Read to his friends, family, and superiors.

During his last Tuesday’s closing remarks, Assistant District Attorney for Norfolk County, Adam Lally, referred to Proctor’s texts as “indefensible,” although he clarified that they had no bearing on the investigation.

Lally dismissed the defense’s cover-up claim as “rampant speculation.”

Read allegedly told first responders that Lally had struck O’Keefe more than once. According to vehicle data, on January 29, at midnight, she reversing her SUV about 62 feet at 24 mph near Brian Albert’s house.

Evidence, according to Lally, proved she hit him. Authorities discovered O’Keefe’s hair and DNA on the back of the car, along with a broken tail light.

According to Lally, nobody at the party remembered seeing O’Keefe at Albert’s house.

Karen Read dropped O’Keefe off at Albert’s house, drove home, and ran away in a panic, breaking the tail lamp, according to defense attorney Alan Jackson. Hours later, she discovered her partner was vanished.

Using surveillance footage from O’Keefe’s house, the defense presented evidence of Read reversing her SUV into her boyfriend’s vehicle on her way out to find him. O’Keefe’s iPhone, according to Jackson, recorded dozens of steps around the moment that prosecutors claim he was struck. It could have been Albert’s basement down those steps.

In contrast to the prosecution, Karen Read lawyers were able to prove O’Keefe’s death was the result of third-party wrongdoing. A BATFE agent suspected of O’Keefe’s murder exchanged passionate texts with Read.

Before the Albert’s house party, Jackson thought that Karen Read had abandoned him at a pub, which had infuriated agent Brian Higgins. Jackson thought O’Keefe may have fallen and struck his skull during a fight between Higgins and O’Keefe at Albert’s house over Read.

Higgins claimed that he had never seen O’Keefe at Albert’s house and that Karen Read lack of emotion didn’t bother him.

O’Keefe’s injuries should have been worse if he had been struck by a car traveling more than 20 mph, according to a forensic engineer who assessed law enforcement’s case management for the Department of Justice, as reported by The Associated Press.

Expert Andrew Rentschler reportedly told the Associated Press, “We do not have sufficient evidence in this case to ascertain which specific event caused the injury.”

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The Supreme Court says Trump has absolute immunity for core acts

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The Supreme Court says Trump has absolute immunity for core acts

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Chip Somodevilla/Getty Images

(VOR News) – The United States Supreme Court ruled in a 6-3 decision that a former president is entitled to a presumption of immunity for his official activities and has complete immunity for his essential constitutional duties. The decision was ideologically fraught.

Nevertheless, his unofficial actions render him susceptible to consequences. The Supreme Court concurrently remanded the case to the trial judge to determine whether any of the actions taken by the former president, Donald Trump, were part of his official duties and, as a result, exempt from prosecution.

The Supreme Court decision regarding this matter is likely to ensure that the litigation against Trump will not be heard before the election and will not be heard until after he has lost his reelection campaign. In the event of an additional election, Trump may either instruct the Justice Department to withdraw the accusations against him or attempt to pardon himself in the two ongoing federal cases.

Chief Justice John Roberts, who was endorsed by his conservative colleagues, authored the Supreme Court judgment. Ketanji Brown Jackson, Sonia Sotomayor, and Elena Kagan, the three liberal justices, expressed their disagreement.

Roberts acknowledged that this was an unusual situation.

He criticized the subordinate courts for “rendering their decisions on a highly expedited basis” and asserted that no court has yet considered how to differentiate between official and unofficial actions. According to him, the lower courts “did not conduct an analysis of the conduct alleged in the indictment to determine which of it should be classified as official and which as unofficial.”

“Trump asserts a far broader immunity than the limited one we have recognized,” according to Roberts. Nevertheless, the perspective also disproved some of the most significant allegations made against the previous president.

“In light of the President’s official relationship to the office held by that individual, certain allegations—such as those involving Trump’s discussions with the Acting Attorney General—are easily categorized,” said the attorney general. Alternatively, “Trump is … absolutely immune from prosecution for the alleged conduct involving his discussions with Justice Department officials.”

The allegations of election interference against Trump will not be subject to a trial for several months as a result of Judge Tanya Chutkan’s decision to return the matter to trial on Monday.

Judge Chutkan anticipated that the trial preparations would necessitate approximately three months prior to the immunity case. She is now obligated to ascertain which of the allegations in the Trump indictment should be pursued further and which are associated with official conduct that is exempt from prosecution under the Supreme Court’s ruling.

Justice Sonia Sotomayor stated in her dissenting opinion that the majority “in effect, completely insulate[s] Presidents from criminal liability.”

“Today’s decision to grant criminal immunity to former Presidents fundamentally alters the institution of the Presidency.” According to her perspective, “It is a mockery of the principle, which is fundamental to our Constitution and system of government, that no man is above the law.”

“The Supreme Court  grants former President Trump all the immunity he requested and more, relying on little more than its own misguided wisdom about the necessity of “bold and unhesitating action” by the President.”

Trump may request further delays, as immunity concerns are among the few that can be challenged prior to trial, even when Judge Chutkan separates the constitutional granules from the chaff.

The Supreme Court rendered its verdict on Monday, months after deciding to hear the case on February 28 and scheduling arguments for two months later.

Critics of the Supreme Court contend that the justices may have examined the case as early as December, when special counsel Jack Smith of the Justice Department unsuccessfully requested that the same issues be considered as those that Trump subsequently raised.

This is in striking contrast to the way in which the court has handled previous cases involving presidential authority. In 1974, the justices issued a decision against President Richard Nixon just sixteen days after hearing oral arguments.

Justice William Rehnquist abstained from voting in the 8-0 decision as a result of his personal relationship with specific authorities who were accused of malfeasance in the case. This year, the court unanimously determined that states were unable to exclude Trump from the ballot in less than a month.

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Prince Harry Opens Up About Grief And Bereavement

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Eagles singer Don Henley sues for return of handwritten ‘Hotel California’ lyrics

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Don Henley | AP News Image

NEW YORK — Don Henley, the Eagles’ singer, filed a lawsuit in New York on Friday to restore his handwritten notes and song lyrics from the band’s classic album “Hotel California”.

The civil complaint was filed in Manhattan federal court in March after prosecutors abruptly dropped criminal charges against three collectibles specialists suspected of attempting to sell the documents.

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Henley | AP News Image

Eagles singer Don Henley sues for return of handwritten ‘Hotel California’ lyrics

When the criminal prosecution against rare books dealer Glenn Horowitz, former Rock & Roll Hall of Fame curator Craig Inciardi, and rock memorabilia vendor Edward Kosinski was dismissed, the Eagles co-founder insisted the pages were stolen and pledged to file a lawsuit.

“Hotel California,” published by the Eagles in 1977, is the third-best-selling album in the United States.

“These 100 pages of personal lyric sheets belong to Mr. Henley and his family, and he has never authorized defendants or anyone else to peddle them for profit,” Henley’s attorney, Daniel Petrocelli, said in an emailed statement Friday.

According to the lawsuit, the handwritten pages are still in the custody of Manhattan District Attorney Alvin Bragg’s office, which declined to comment on the case Friday.

Lawyers for Kosinski and Inciardi criticized the legal action as frivolous, stating that the criminal prosecution was dropped after it was discovered that Henley deceived prosecutors by omitting important material.

“Don Henley is desperate to rewrite history,” Kosinski’s lawyer, Shawn Crowley, said in an emailed statement. “We look forward to litigating this case and bringing a lawsuit against Henley to hold him accountable for his repeated lies and misuse of the justice system.”

In a separate statement, Stacey Richman, Inciardi’s lawyer, said that the lawsuit seeks to “bully” and “perpetuate a false narrative.”

A lawyer for Horowitz, who isn’t named as a defendant because he doesn’t own the files, did not respond to an email requesting comment.

During the trial, the men’s lawyers claimed that Henley sent the lyrical pages to a writer who worked on an unpublished Eagles biography before selling the handwritten sheets to Horowitz. He sold them to Inciardi and Kosinski, who began auctioning some of the pages in 2012.

henley

Don Henley | AP News Image

Eagles singer Don Henley sues for return of handwritten ‘Hotel California’ lyrics

The criminal case was quickly abandoned when prosecutors acknowledged that defense lawyers had been caught off guard by 6,000 pages of conversations involving Henley, his attorneys, and associates.

Prosecutors and the defense said they only acquired the materials when Henley and his lawyers decided to forgo their attorney-client privilege at the last minute, which protected legal discussions.

Judge Curtis Farber, who presided over the nonjury trial that began in late February, stated that witnesses and their lawyers used attorney-client privilege “to obfuscate and hide information that they believed would be damaging” and that prosecutors “were apparently manipulated.”

SOURCE – (AP)

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