Health
Drug-Resistant Strains Of Mpox Threaten Homosexual Men Experiencing Unprotected Sex.
(VOR News) – A recent study found that gay and bisexual men who engage in Mpox unprotected anal intercourse as the receptive partner are five times more likely to get the mpox virus.
The study and the release of a second report on mpox cases in California and Illinois that are associated with a strain that is resistant to first-line treatment with tecovirimat coincide.
Since not all viruses from cases are genetically tested, “these findings likely underestimate the frequency of this newly recognized drug-resistant variant,” a team led by Crystal Gigante noted. Her job is with the Centers for Disease Control and Prevention (CDC) in the United States.
Previously known as monkeypox, mpox is a quickly spreading virus that is primarily disseminated by close skin-to-skin contact, especially during sexual encounters. Symptoms include fever, severe sores or rashes, and enlarged lymph nodes.
During the outbreak in 2022 and 2023, mpox spread to other countries.
Now that a new, potentially more deadly strain of the virus has emerged within the Democratic Republic of the Congo, the WHO has declared a public health emergency of worldwide significance.
Both of the new studies on MPox were published in the CDC journal Morbidity and Death Weekly Report on October 10. A study sought to determine whether specific sexual activities raise the risk of viral transmission because gay and bisexual men have been identified as the primary carriers of MPX outside of Africa.
A group led by CDC researcher Anna Chard looked through documents pertaining to the sexual activities of almost 1,500 American men under 50 who said they had sex with other men. Of these, 457 had contracted MPox, whereas 1,030 had not yet shown symptoms of the illness.
Chard’s team, Mpox, addressed guys with “close contact” with an MPV patient.
After accounting for other factors, Chard’s team found that the primary risk factor for mpox infection in this group was condom-free, receptive anal sex, which increased a person’s risk five times higher than that of men who hadn’t engaged in this unprotected form of sex.
The CDC researchers emphasized that while condoms can significantly lower the risk of mpox transmission, they are not infallible.
According to Chard and colleagues, “condoms alone might not prevent all exposures to [the virus] because rash can occur on other parts of the body and transmission can occur through other routes, including saliva and respiratory secretions” .
However, vaccination with the Jynneos vaccine is one effective means of preventing illness. Only 1 in 4 of the almost 2 million Americans who were eligible for the immunization had received both doses, according to experts.
Even among inoculated gay and bisexual men, booster shots may still be required. Current study indicates that the thempox immunization loses effectiveness against the virus after a year.
Drug-resistant mpox spreads across the US.
So immunization may be even more necessary. Gigante and colleagues report that modifications to the thempox virus brought on by extended therapy may result in viral resistance to first-line drugs, such as tecoviramat.
These resistant viruses “have been reported since 2022,” according to the researchers, and new cases keep popping up.
The latest data shows that between October 2023 and mid-February 2024, a cluster of five comparable cases were reported in California, eight more in Illinois, two in Louisiana, two in Texas, and one in New York.
Even though Gigante’s team had to admit two patients to the hospital in order to treat their pain, all 17 of the drug-resistant mpox patients whose medical records were available “reported mild (or not severe) mpox disease.”
However, the new data “highlight the urgent need for additional therapeutics for treatment of mpox” and most likely understate the prevalence of this strain of the virus, according to the researchers.
SOURCE: MP
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Health
SARMs: Understanding How they Work
Selective Androgen Receptor Modulators (SARMs) are common in the bodybuilding and fitness world for the anabolic benefits of testosterone without the same magnitude of harmful side effects.
SARMs are synthetic drugs initially designed to help cancer patients with muscle wasting. They achieve this by signaling tissues in the body, specifically muscle and bone, to grow. However, SARMs are in no way limited to the confines of the cancer patient; they are for regular guys who want to look better.
Understanding Selective Androgen Receptor Modulators (SARMs): When traditional anabolic steroids lock with androgen receptors in the body, they tell muscles to get bigger and communicate this message to other androgen receptor-containing tissues. That’s why strength—and performance-boosting drugs of this kind carry side effects many users want to avoid.
SARMs are designed to zero in on particular tissues to deliver the desired effects with hardly any side effects. They work differently in the tissues they are intended to target, much like testosterone does, but not quite as well. They are selective, activating the androgen receptor almost exclusively in muscle and bone.
This “selectivity” offers two main benefits. On the one hand, it means SARMs should have very strong anabolic effects in the tissues they target; on the other hand, they should be able to achieve these strong anabolic effects using a little bit of the dose of anabolic steroids that one would need to use to achieve similar effects.
This means you won’t have any lingering effects. SARMs can be very advantageous. They can do many good things, especially in the area of muscle growth and improvement in physical performance.
Through their specific focus on the androgen receptors found in muscle tissues while reducing activity at other surrounding locations throughout the body, selective androgen receptor modulators (SARMs) are designed to quicken various sought-after anabolic results such as bigger muscle mass, improved physical endurance, and more robust bones.
This is achieved with the added promise of relieving or even evading the typically dreaded side effects of non-specific androgenic steroids.
Adverse effects such as benign prostatic hyperplasia, accelerated male pattern baldness, severe acne, gynecomastia, aggression and mood disturbances, and suppression of natural testosterone production can occur. The ability of SARMs to undo these effects has sparked tremendous interest.
Types of SARMs
Among the many SARMs researchers have combined and tested for potential medical use, few, in particular, have become favored by bodybuilders and physique athletes for their remarkable muscle- and strength-building effects. They are:
- Ostarine (MK-2866): Ostarine (MK-2866) is one of the most thoroughly studied selective androgen receptor modulators (SARMs) documented to date. This chemical compound has gotten attention due to its ability to massively boost muscle mass and help maintain muscle power and energy purposes. Training fights against the post-injury process, growth depletion from the tumor, MS, and other illnesses that harm the muscles and bones. Beyond that, researchers wonder whether ostarine could enable someone to fight against osteoporosis (bone loss) and sarcopenia (lots of muscle without replacing it). In the field of fitness and bodybuilding, daily ostarine doses of 12.5mg-25mg are commonly used.
- Ligandrol (LGD-4033): Ligandrol (LGD-4033) was intended to prevent muscle-wasting diseases. Yet it has gathered considerable attention due to its ability to aid densely packed, high-quality muscle growth and strength and even quicken fat loss. Moreover, its anabolic potential exceeds that of numerous conventional steroids, even though Ligandrol is labeled as a SARM. The typical dose taken by many bodybuilders ranges from 5mg to 20mg daily.
- Testolone (RAD-140): Testolone (RAD-140) has the highest muscle-building potential among all the SARMs presently under research. Although it was initially researched as a potential male contraceptive pill due to its ability to boost protein synthesis and nitrogen retention, Testolone can facilitate dramatic lean mass and strength gains, making it comparable to ultra-powerful anabolic agents like Trenbolone. Recommended bodybuilding doses generally fall within 10 to 20mg daily.
Potential Risks of Using SARMs
The use of SARMs raises a big concern for human health. Their potential to cause harm to several body systems is not yet known. Nevertheless, the healthcare community is beginning to talk about the fact that they may lead to:
- Lessened endogenous testosterone creation and Hypothalamic-Pituitary-Testicular Axis function.
- Detrimental consequences on cholesterol and lipid profiles: This may come about due to the probable strain sustained by the heart and the escalated risk of confronting heart attacks or strokes.
- Problems with liver toxicity, particularly when SARMs are taken by mouth
- Difficulties with eyesight include yellow tint aberration or photophobia.
- Masculinizing effects, such as the growth of body hair, deepening of the voice, and disruptions in the menstrual cycle, are common in women.
Though SARMs were designed to target specific tissues as opposed to conventional steroids, they are still powerful substances that can have a significant negative impact on many critical bodily functions if used carelessly.
Legality and Regulation of SARMs
The complicated legality and regulation of SARMs are also part of the bigger picture. SARMs have not been FDA-approved for human consumption and are not labeled/packaged for human use. They are classified as investigational compounds. In Canada, their sale and distribution for purposes not described in these laws is not in the general public’s best interest and is not therapeutically necessary.
It’s important to understand that SARMs must be used carefully and supervised by trained medical personnel to explore their Selective Androgen Receptor Modulators (SARMs).
Taking them as a medication is a way of going overboard and may have side effects that we’re not yet fully aware of. The real danger, of course, comes when ignorant or overzealous people self-medicate. Self-medication with these kinds of substances is not similar to steroid use because it involves taking some level of medical supervision out of the equation. And this can only mean increased risks.
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Health
Canada Records Its First Case of Human Avian Influenza
The health ministry of British Columbia, Canada, reports that the first probable human case of the avian influenza virus (H5N1) was found in a hospitalized teenager from the Fraser Valley. The adolescent tested positive for the virus, and health officials are investigating the source of exposure.
According to Provincial Health Officer Dr. Bonnie Henry, an investigation is underway to discover how the patient was infected, though the source is likely an animal or a bird. No other illnesses have shown evidence of person-to-person transmission. However, Dr. Bonnie warns that a pandemic may ensue if this occurs.
Since early October, at least 22 avian flu outbreaks in BC poultry have been documented, and multiple detections in wild birds throughout the province. In 2014, Canada reported an H5N1 death involving a Canadian who had just returned from a trip to China.
According to Health Canada, outbreaks of avian influenza A(H5N1) in domestic and wild birds, as well as some animals, have lately developed and spread throughout Europe and North America, including Canada, Central and South America, the sub-Antarctic areas, and Antarctica.
The Canadian government is now reacting to an influenza A (H5N1) outbreak in farmed birds and wildlife across the country.
Influenza A(H5N1) is a subtype of the avian influenza virus that primarily infects birds. It has also been found in other animals, resulting in rare and infrequent human infections.
Human instances of influenza A(H5N1) have predominantly resulted from zoonotic transmission by direct contact with infected birds (dead or alive) or polluted settings. Human-to-human transmission is extremely rare, and there is no evidence of ongoing transmission between humans.
The virus mostly affects the respiratory tract but can also produce gastrointestinal and central nervous system symptoms. Infection can cause severe sickness and even death.
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Health
Nepal Mad Honey Gains Attention from Health Enthusiasts
High in the rugged mountain cliffs of Nepal, an extremely rare and mystique substance known as Mad Honey has gained a lot of attention. Health enthusiasts, researchers and adventure seekers are diving deep for this one thing.
For many centuries, the indigenous people have known Mad Honey for its hallucinogenic properties and tremendous health benefits. Mad Honey has now begun to be recognized worldwide as a strong superfood in health and wellness.
So, if you are wondering what Mad Honey from Nepal is,
In Nepal, Mad Honey is a kind of Honey that the bees produce by feeding on nectar from the Rhododendron and other wildflowers. These wildflowers often involve several medicinal flowering herbs and shrubs that grow at extremely high altitudes in Nepal.
The nectar collected from these plants usually contains Grayanotoxin, a naturally occurring neurotoxin. When Honey made from Wildflower nectar reaches the bloodstream, it can cause mild intoxication, dizziness and even hallucinations while giving the body medicinal effects.
Mad Honey – The history of Superfood usage by Gurungs
Even though Mad Honey can turn people insane, it has been highly valued for therapeutic uses. This product has been well-known in traditional medicine for its health benefits in the Gurung and Kulung communities.
These traditional communities have been practicing the harvest of mad Honey for centuries. They have been using it as a regular dietary supplement, which makes them strong and vigorous.
These tribesmen, also known as brave Gurkhas and involved in two great world wars, showed greater bravery. The story has it all: they have been using mad Honey since childhood.
These communities use it as cough syrup and antiseptic, enhancing vitality, reducing inflammation and digestion issues and pain relief. Its healing properties make it useful for therapeutic use within global communities. Because of these properties, it is often considered a superfood.
Why Mad Honey is considered a SuperFood from the Himalayas
By now, you may be wondering what benefits it brings to the body, so it is categorized as a superfood. Let’s look at these superfood benefits, which are increasingly popular within wellness communities.
- Pain Relief
Mad Honey is a natural pain reliever and analgesic for arthritis and other body pains. Its grayanotoxins have mild analgesic action. This superfood helps reduce internal inflammation and discomfort and could be used as a home remedy for the natural treatment of body pains.
- Improves Immunity and Energy flow
Cliff Honey contains Antioxidants, vitamins, and minerals in a more concentrated and purest form, which will improve your immune system. It helps build a body resilient to infections and illnesses, which makes one immune to sickness and diseases. Also, the natural sugar in mad Honey gets quickly absorbed into the bloodstream, providing a sustainable energy supply throughout the day.
- Digestive Aid
With its antibacterial properties and the enzymes it contains, mad Honey helps improve gut bacteria. This superfood has been considered the best home remedy for treating digestive problems such as gastritis and constipation for hundreds of years. Therefore, mad Honey is a very welcome addition to a healthy diet.
- Improvement of Brain Functions
Some studies even say Mad Honey from Nepal can bring mental clarity and cognitive functions. Neurotoxic compounds might slightly alter brain chemistry, increasing awareness and focus. As the superfood does impair cognitive retardation, it does reduce the chances of neurodegenerative conditions like Alzheimer’s and Parkinson’s diseases.
- Potential Aphrodisiac
In some parts of the world, Mad Honey claims to have some aphrodisiac properties. There have not been any scientific claims made that this specified product can enhance sexual performance and drive, but personal reports on the subject do suggest that mad Honey does contribute to raising energy levels. Some users have claimed it helped them with sexual libido.
- Support heart health
Mad Honey can reduce inflammation, improve cholesterol levels and lower blood pressure, making it the best approach for holistic health. It also lowers the risk of cardiovascular issues such as heart attacks and strokes.
- Combat aging and cellular damage
The antioxidant property of Mad Honey from Nepal helps protect the body from oxidative stress and free radical damage, which are considered major contributors to aging and chronic diseases. The harmful molecules are neutralized, which promotes healthy skin with reduced wrinkles, fine lines and other signs of aging.
Important Considerations:
The benefits of Mad Honey seem to include boosting immunity, enhancing vitality and preventing diseases, but a slight overdose can cause complications. Mad Honey should always be consumed in moderation. Excessive intake can lead to adverse effects, including nausea, dizziness and sometimes unconsciousness if taken in large quantities. Always consult a healthcare provider before adding any new supplement to your diet.
How You Can Experience the Benefits of Mad Honey from Nepal
Now that you have learned much about mad Honey, its usage history and amazing benefits, perhaps you might wonder where you can get safe, authentic and genuine mad Honey. Here is a guide for you to try this superfood called Mad Honey.
- Finding Reliable Suppliers
Since mad Honey is rare and hard to source from high altitudes in Nepal, finding a valid and trusted supplier is necessary. Only authentic mad honey sellers provide information about where and how it was harvested. They offer lab-tested certifications and transparency in sourcing and pricing.
- How to Use Mad Honey
Mad Honey can be consumed in several ways. The most recommended usage is to take it directly on an empty stomach in the morning. It may be mixed with tea, smoothies, and drizzled over fruit and yogurt, but one should be aware of the amount taken since you start with very little, especially for those unexposed to it. One teaspoon of Mad Honey is generally the recommended dosage to start with and increase with time.
- Integrating Mad Honey into Your Wellness Routine
Integrate Mad Honey into your everyday wellness routine to reap the most from this superfood. Blend this superfood with other home remedies like turmeric, ginger and other wellness products. You can add it to other herbal medicines and natural shilajit to achieve overall wellness.
Conclusion
Mad Honey is not just a honey that turns people mad; it does offer incredible health benefits. This superfood can offer pain relief, help in digestion, boost immunity and give a hallucinogenic experience. The strong Honey originating from the Himalayas offers a lot that can be integrated into one’s everyday wellness routine.
If you are ready to take the plunge and experience the benefits of Mad Honey, which are as rare as potent, then source it responsibly and take everything in moderation. Let the magic of the Himalayas work to transform your health and vitality, one drop of Mad Honey at a time.
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